| Reaction Details |
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 | Report a problem with these data |
| Target | Gag-Pol polyprotein |
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| Ligand | BDBM151088 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Integrase Assay |
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| IC50 | 58700±n/a nM |
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| Citation |  Danter, W; Threlfall, C; Guizzetti, S; Marin, J Compounds and method for treatment of HIV US Patent US8987272 Publication Date 3/24/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Gag-Pol polyprotein |
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| Name: | Gag-Pol polyprotein |
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| Synonyms: | Integrase | POL_HV1U4 | gag-pol |
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| Type: | Protein |
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| Mol. Mass.: | 161130.06 |
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| Organism: | Human immunodeficiency virus type 1 (HIV-1) |
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| Description: | P24740 |
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| Residue: | 1428 |
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| Sequence: | MGARASVLSGKKLDSWEKIRLRPGGNKKYRLKHLVWASRELEKFTLNPGLLETAEGCQQI
LGQLQPALQTGTEELRSLYNTVAVLYCVHQRIDVKDTKEALNKIEEMQNKNKQRTQQAAA
NTGSSQNYPIVQNAQGQPVHQALSPRTLNAWVKVVEDKAFSPEVIPMFSALSEGATPQDL
NMMLNVVGGHQAAMQMLKDTINEEAAEWDRLHPVHAGPIPPGQMREPRGSDIAGTTSTVQ
EQIGWMTGNPPIPVGDIYRRWIILGLNKIVRMYSPVSILDIRQGPKEPFRDYVDRFFKTL
RAEQATQDVKNWMTETLLVQNANPDCKSILRALGPGATLEEMMTACQGVGGPGHKARVLA
EAMSQVQQTSIMMQRGNFRGPRRIKCFNCGKEGHLAKNCRAPRKKGCWKCGKEGHQMKDC
TERQANFLRENLAFQQGEAREFSSEQTRANSPTSRNLWDGGKDDLPCETGAERQGTDSFS
FPQITLWQRPLVTVKIGGQLIEALLDTGADDTVLEDINLPGKWKPKIIGGIGGFIKVRQY
DQILIEICGKKTIGTVLVGPTPVNIIGRNMLTQIGCTLNFPISPIETVPVKLKPEMDGPK
VKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFREL
NKRTQDFWEVQLGIPHTAGLKKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNETP
GVRYQYNVLPQGWKGSPSIFQSSMTKILEPFRSQHPDIVIYQYMDDLYVGSDLEIGQHRA
KIEELRAHLLSWGFITPDKKHQKEPPFLWMGYELHPDKWTVQPIQLPEKDSWTVNDIQKL
VGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVTLTEEAELELAENREILKDPVHGVYYD
PSKDLVAEIQKQGQDQWTYQIYQEPFKNLKTGKYARKRSAHTNDVKQLTEVVQKVSTESI
VIWGKIPKFRLPIQKETWEAWWMEYWQATWIPEWEFVNTPPLVKLWYQLEKDPIAGAETF
YVDGAANRETKLGKAGYVTDRGRQKVVSLTETTNQKTELHAIHLALQDSGSEVNIVTDSQ
YALGIIQAQPDRSESEIVNQIIEKLIEKEKVYLSWVPAHKGIGGNEQVDKLVSSGIRKVL
FLDGIDKAQEDHEKYHCNWRAMASDFNLPPVVAKEIVASCNKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKVIHTDNGSN
FTSAAVKAVCWWANIQQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQISKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCMAGRQDED
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| BDBM151088 |
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| n/a |
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| Name | BDBM151088 |
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| Synonyms: | US8987272, COTI-HIV-1 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H12FN5O3 |
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| Mol. Mass. | 317.2752 |
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| SMILES | Cn1cnc(-c2nnc(Cc3ccc(F)cc3)o2)c(O)\c1=N\O |
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| Structure | 
|
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