| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Endothelial lipase |
|---|
| Ligand | BDBM152293 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzymatic Assay |
|---|
| pH | 8±n/a |
|---|
| IC50 | 6453±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Lloyd, J; Qiao, JX; Finlay, H; Neels, J; Pi, Z; Hu, CH; Wang, TC Pyridinedione carboxamide inhibitors of endothelial lipase US Patent US8993557 Publication Date 3/31/2015 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Endothelial lipase |
|---|
| Name: | Endothelial lipase |
|---|
| Synonyms: | EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 56805.62 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9Y5X9 |
|---|
| Residue: | 500 |
|---|
| Sequence: | MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPE
HEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVV
VDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGN
FVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHID
IYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS
NRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKN
MGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGAS
QSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWF
RKCRDGWRMKNETSPTVELP
|
|
|
|---|
| BDBM152293 |
|---|
| n/a |
|---|
| Name | BDBM152293 |
|---|
| Synonyms: | US8993557, 31 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H21N3O3 |
|---|
| Mol. Mass. | 327.3776 |
|---|
| SMILES | Cn1ccc(C(=O)NCc2ccccc2N2CCCC2)c(O)c1=O |
|---|
| Structure | 
|
|---|
Search and Browse
