Reaction Details |
| Report a problem with these data |
Target | Neuraminidase |
---|
Ligand | BDBM4934 |
---|
Substrate/Competitor | BDBM4702 |
---|
Meas. Tech. | Neuraminidase Inhibition Assay |
---|
pH | 6.5±n/a |
---|
Temperature | 310.15±n/a K |
---|
IC50 | 2±1 nM |
---|
Citation | Chand, P; Kotian, PL; Dehghani, A; El-Kattan, Y; Lin, TH; Hutchison, TL; Babu, YS; Bantia, S; Elliott, AJ; Montgomery, JA Systematic structure-based design and stereoselective synthesis of novel multisubstituted cyclopentane derivatives with potent antiinfluenza activity. J Med Chem44:4379-92 (2001) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Neuraminidase |
---|
Name: | Neuraminidase |
Synonyms: | Influenza A Virus Neuraminidase | NA | NRAM_I57A5 | Neuraminidase A |
Type: | Enzyme |
Mol. Mass.: | 52000.86 |
Organism: | Influenza A virus (A/Singapore/1/57(H2N2)) |
Description: | Q6XUE4 |
Residue: | 469 |
Sequence: | MNPNQKIITIGSVSLTIATVCFLMQIAILATTVTLHFKQHECDSPASNQVMPCEPIIIER
NITEIVYLNNTTIEKEICPEVVEYRNWSKPQCQITGFAPFSKDNSIRLSAGGDIWVTREP
YVSCDPGKCYQFALGQGTTLDNKHSNGTIHDRIPHRTLLMNELGVPFHLGTKQVCVAWSS
SSCHDGKAWLHVCVTGDDRNATASFIYDGRLVDSIGSWSQNILRTQESECVCINGTCTVV
MTDGSASGRADTRILFIKEGKIVHISPLSGSAQHIEECSCYPRYPDVRCICRDNWKGSNR
PVIDINMEDYSIDSSYVCSGLVGDTPRNDDSSSNSNCRDPNNERGNPGVKGWAFDNGDDV
WMGRTINKDSRSGYETFKVIGGWSTPNSKSQVNRQVIVDNNNWSGYSGIFSVEGKSCINR
CFYVELIRGRPQETRVWWTSNSIVVFCGTSGTYGTGSWPDGANINFMPI
|
|
|
BDBM4934 |
---|
BDBM4702 |
---|
Name | BDBM4934 |
Synonyms: | (2R,3R,4S)-4-carbamimidamido-3-acetamido-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid | GG167 | Zanamivir |
Type | Small organic molecule |
Emp. Form. | C12H20N4O7 |
Mol. Mass. | 332.3098 |
SMILES | [H][C@]1([#8]-[#6](=[#6]-[#6@H](\[#7]=[#6](/[#7])-[#7])-[#6@H]1-[#7]-[#6](-[#6])=O)-[#6](-[#8])=O)[#6@H](-[#8])-[#6@H](-[#8])-[#6]-[#8] |r,c:3| |
Structure |
|