| Reaction Details |
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 | Report a problem with these data |
| Target | Epidermal growth factor receptor [1-973] |
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| Ligand | BDBM152779 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In vitro EGFR TK Inhibition Assays |
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| Temperature | 298.15±n/a K |
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| IC50 | 15.4±2.33 nM |
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| Comments | extracted |
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| Citation |  Hu, M; Ye, W; Li, J; Zhong, G; He, G; Xu, Q; Zhang, Y Synthesis and evaluation of salicylanilide derivatives as potential epidermal growth factor receptor inhibitors. Chem Biol Drug Des85:280-9 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Epidermal growth factor receptor [1-973] |
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| Name: | Epidermal growth factor receptor [1-973] |
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| Synonyms: | EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor (EGFR) | HER1 | Receptor tyrosine-protein kinase erbB-1 |
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| Type: | Protein |
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| Mol. Mass.: | 108055.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00533[1-973] |
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| Residue: | 973 |
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| Sequence: | MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMAR
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| BDBM152779 |
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| n/a |
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| Name | BDBM152779 |
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| Synonyms: | 4-(3-(Piperidin-1-yl)propoxy)-N-(3-chloro-4-fluorophenyl)-2-hydroxybenzamide (12b) |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24ClFN2O3 |
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| Mol. Mass. | 406.878 |
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| SMILES | Oc1cc(OCCCN2CCCCC2)ccc1C(=O)Nc1ccc(F)c(Cl)c1 |
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| Structure | 
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