| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Epidermal growth factor receptor [1-973] |
|---|
| Ligand | BDBM152780 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In vitro EGFR TK Inhibition Assays |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | 23.0±3.65 nM |
|---|
| Comments | extracted |
|---|
| Citation |  Hu, M; Ye, W; Li, J; Zhong, G; He, G; Xu, Q; Zhang, Y Synthesis and evaluation of salicylanilide derivatives as potential epidermal growth factor receptor inhibitors. Chem Biol Drug Des85:280-9 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Epidermal growth factor receptor [1-973] |
|---|
| Name: | Epidermal growth factor receptor [1-973] |
|---|
| Synonyms: | EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor (EGFR) | HER1 | Receptor tyrosine-protein kinase erbB-1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 108055.41 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00533[1-973] |
|---|
| Residue: | 973 |
|---|
| Sequence: | MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMAR
|
|
|
|---|
| BDBM152780 |
|---|
| n/a |
|---|
| Name | BDBM152780 |
|---|
| Synonyms: | 4-(3-(Piperidin-1-yl)propoxy)-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide (13b) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H24ClN3O5 |
|---|
| Mol. Mass. | 433.885 |
|---|
| SMILES | Oc1cc(OCCCN2CCCCC2)ccc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O |
|---|
| Structure | 
|
|---|
Search and Browse
