Reaction Details |
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Target | E3 ubiquitin-protein ligase Mdm2 |
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Ligand | BDBM152963 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Homogeneous Time-Resolved Fluorescence (HTRF) Assay |
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IC50 | 4.39±n/a nM |
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Citation | Bartkovitz, DJ; Chu, X; Vu, BT; Zhao, C; Fishlock, D Substituted pyrrolidine-2-carboxamides US Patent US8993614 Publication Date 3/31/2015 |
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More Info.: | Get all data from this article, Assay Method |
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E3 ubiquitin-protein ligase Mdm2 |
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Name: | E3 ubiquitin-protein ligase Mdm2 |
Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein |
Type: | Oncoprotein |
Mol. Mass.: | 55196.54 |
Organism: | Homo sapiens (Human) |
Description: | Q00987 |
Residue: | 491 |
Sequence: | MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
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BDBM152963 |
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n/a |
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Name | BDBM152963 |
Synonyms: | US8993614, 24 |
Type | Small organic molecule |
Emp. Form. | C36H36Cl2F2N4O8 |
Mol. Mass. | 761.596 |
SMILES | COc1cc(ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@@](C#N)([C@H]1c1cccc(Cl)c1F)c1ccc(Cl)cc1F)C(=O)OC(C)OC(=O)NCC(O)=O |r| |
Structure |
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