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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Amyloid-beta precursor protein | ||
| Ligand | BDBM155107 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Release Assay | ||
| Temperature | 310.15±n/a K | ||
| IC50 | 1.6±n/a nM | ||
| Comments | extracted | ||
| Citation |  Karlstrom, S; Csjernyik, G; Swahn, B; Sandberg, L; Kolmodin, K; Soderman, P; Ohberg, L 2H-imidazol-4-amine compounds and their use as BACE inhibitors US Patent US9000182 Publication Date 4/7/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Amyloid-beta precursor protein | |||
| Name: | Amyloid-beta precursor protein | ||
| Synonyms: | A4 | A4_HUMAN | ABPP | AD1 | AICD-50 | AICD-57 | AICD-59 | AID(50) | AID(57) | AID(59) | APP | APPI | Alzheimer disease amyloid protein | Amyloid beta A4 protein | Amyloid beta Protein | Amyloid beta protein (sAPPbeta) | Amyloid beta protein Abeta(1-42) | Amyloid intracellular domain 50 | Amyloid intracellular domain 57 | Amyloid intracellular domain 59 | Amyloid protein (Abeta42b) | Amyloid β-protein (Aβ42) | Beta amyloid A4 protein | Beta-APP40 | Beta-APP42 | Beta-amyloid protein 40 | Beta-amyloid protein 42 | C31 | C83 | C99 | CVAP | Cerebral vascular amyloid peptide | Gamma Secretase | Gamma-CTF(50) | Gamma-CTF(57) | Gamma-CTF(59) | Gamma-secretase | Gamma-secretase C-terminal fragment 50 | Gamma-secretase C-terminal fragment 57 | Gamma-secretase C-terminal fragment 59 | P3(40) | P3(42) | PN-II | PreA4 | Protease nexin-II | S-APP-alpha | S-APP-beta | Soluble APP-alpha | Soluble APP-beta | beta-Amyloid Precursor Protein (APP) | ||
| Type: | Single-pass type I membrane protein | ||
| Mol. Mass.: | 86890.41 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P05067 | ||
| Residue: | 770 | ||
| Sequence: |
| ||
| BDBM155107 | |||
| n/a | |||
| Name | BDBM155107 | ||
| Synonyms: | US9000182, 15, isomer 1 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H23ClN4O | ||
| Mol. Mass. | 418.919 | ||
| SMILES | CC1=N[C@]2(N=C1N)c1cc(ccc1C[C@@]21CC[C@H](O)CC1)-c1cc(Cl)cc(c1)C#N |r,wU:3.2,wD:14.15,17.20,c:4,t:1,(1.87,3.15,;2.64,1.81,;1.73,.57,;2.64,-.68,;4.1,-.2,;4.1,1.34,;5.44,2.11,;1.17,-1.15,;-.16,-.38,;-1.49,-1.15,;-1.49,-2.69,;-.16,-3.46,;1.17,-2.69,;2.64,-3.17,;3.54,-1.92,;4.31,-.59,;5.85,-.59,;6.62,-1.92,;8.16,-1.92,;5.85,-3.26,;4.31,-3.26,;-2.83,-.38,;-2.83,1.16,;-4.16,1.92,;-4.16,3.46,;-5.5,1.16,;-5.5,-.38,;-4.16,-1.15,;-6.83,-1.15,;-8.16,-1.92,)| | ||
| Structure | 
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