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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Beta-secretase 1 | ||
| Ligand | BDBM155115 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | TR-FRET Assay | ||
| pH | 2.5±n/a | ||
| IC50 | 1659±n/a nM | ||
| Comments | extracted | ||
| Citation |  Karlstrom, S; Soderman, P; Rakos, L; Ohberg, L; Kolmodin, K; Sandberg, L Cyclohexane-1,2′-indene-1′,2″-imidazol compounds and their use as BACE inhibitors US Patent US9000183 Publication Date 4/7/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Beta-secretase 1 | |||
| Name: | Beta-secretase 1 | ||
| Synonyms: | ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1) | ||
| Type: | Protein | ||
| Mol. Mass.: | 55755.10 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P56817 | ||
| Residue: | 501 | ||
| Sequence: |
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| BDBM155115 | |||
| n/a | |||
| Name | BDBM155115 | ||
| Synonyms: | US9000183, 1 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H24BrN3O | ||
| Mol. Mass. | 390.317 | ||
| SMILES | CO[C@H]1CC[C@@]2(Cc3cc(C)c(Br)cc3C22N=C(C)C(N)=N2)CC1 |r,wD:5.5,2.1,c:22,t:18,(5.88,-3.04,;5.11,-1.7,;3.57,-1.7,;2.8,-.37,;1.26,-.37,;.49,-1.7,;-.41,-2.95,;-1.88,-2.47,;-3.21,-3.24,;-4.55,-2.47,;-5.88,-3.24,;-4.55,-.93,;-5.88,-.16,;-3.21,-.16,;-1.88,-.93,;-.41,-.46,;-1.66,.45,;-1.18,1.91,;-1.95,3.24,;.36,1.91,;1.13,3.24,;.83,.45,;1.26,-3.04,;2.8,-3.04,)| | ||
| Structure | 
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