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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Amyloid-beta precursor protein | ||
| Ligand | BDBM155142 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Release Assay | ||
| Temperature | 310.15±n/a K | ||
| IC50 | 4.5±n/a nM | ||
| Comments | extracted | ||
| Citation |  Karlstrom, S; Sandberg, L; Soderman, P; Kolmodin, K; Ohberg, L Cyclohexane-1,2′-naphthalene-1′,2″-imidazol compounds and their use as BACE inhibitors US Patent US9000184 Publication Date 4/7/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Amyloid-beta precursor protein | |||
| Name: | Amyloid-beta precursor protein | ||
| Synonyms: | A4 | A4_HUMAN | ABPP | AD1 | AICD-50 | AICD-57 | AICD-59 | AID(50) | AID(57) | AID(59) | APP | APPI | Alzheimer disease amyloid protein | Amyloid beta A4 protein | Amyloid beta Protein | Amyloid beta protein (sAPPbeta) | Amyloid beta protein Abeta(1-42) | Amyloid intracellular domain 50 | Amyloid intracellular domain 57 | Amyloid intracellular domain 59 | Amyloid protein (Abeta42b) | Amyloid β-protein (Aβ42) | Beta amyloid A4 protein | Beta-APP40 | Beta-APP42 | Beta-amyloid protein 40 | Beta-amyloid protein 42 | C31 | C83 | C99 | CVAP | Cerebral vascular amyloid peptide | Gamma Secretase | Gamma-CTF(50) | Gamma-CTF(57) | Gamma-CTF(59) | Gamma-secretase | Gamma-secretase C-terminal fragment 50 | Gamma-secretase C-terminal fragment 57 | Gamma-secretase C-terminal fragment 59 | P3(40) | P3(42) | PN-II | PreA4 | Protease nexin-II | S-APP-alpha | S-APP-beta | Soluble APP-alpha | Soluble APP-beta | beta-Amyloid Precursor Protein (APP) | ||
| Type: | Single-pass type I membrane protein | ||
| Mol. Mass.: | 86890.41 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P05067 | ||
| Residue: | 770 | ||
| Sequence: |
| ||
| BDBM155142 | |||
| n/a | |||
| Name | BDBM155142 | ||
| Synonyms: | US9000184, 11, isomer 1 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H27ClN4O | ||
| Mol. Mass. | 446.972 | ||
| SMILES | CO[C@H]1CC[C@@]2(CC1)CCc1ccc(cc1C21N=C(C)C(N)=N1)-c1cc(Cl)cc(c1)C#N |r,wU:2.1,wD:5.8,c:24,t:20,(8.59,-3.66,;7.82,-2.32,;6.28,-2.32,;5.51,-3.66,;3.97,-3.66,;3.2,-2.32,;3.97,-.99,;5.51,-.99,;2.8,-3.81,;1.32,-4.21,;.23,-3.12,;-1.26,-3.52,;-2.35,-2.43,;-1.95,-.94,;-.46,-.54,;.63,-1.63,;2.11,-1.23,;.87,-.33,;1.34,1.13,;.57,2.47,;2.88,1.13,;3.65,2.47,;3.36,-.33,;-3.04,.15,;-2.64,1.63,;-3.73,2.72,;-3.33,4.21,;-5.22,2.32,;-5.62,.84,;-4.53,-.25,;-7.1,.44,;-8.59,.04,)| | ||
| Structure | 
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