| Reaction Details |
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 | Report a problem with these data |
| Target | Amyloid-beta precursor protein |
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| Ligand | BDBM155395 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence (or Forster) Resonance Energy Transfer (FRET) Assay |
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| pH | 8±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | 3200±n/a nM |
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| Comments | extracted |
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| Citation |  Krafft, GA; Pray, T; Goure, WF Methods of modifying amyloid β oligomers using non-peptidic compounds US Patent US9006283 Publication Date 4/14/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Amyloid-beta precursor protein |
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| Name: | Amyloid-beta precursor protein |
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| Synonyms: | A4 | A4_RAT | AD1 | App | Beta-amyloid protein 42 |
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| Type: | Protein |
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| Mol. Mass.: | 86651.28 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P08592 |
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| Residue: | 770 |
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| Sequence: | MLPSLALLLLAAWTVRALEVPTDGNAGLLAEPQIAMFCGKLNMHMNVQNGKWESDPSGTK
TCIGTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHTHIVIPYRCLVG
EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDSIDSADAEEDDSDVWWGGADTDYADGGEDKVVEVAEEEEVADVEEE
EAEDDEDVEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSVSSQSLLKTTSEPLPQD
PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
QAVPPRPHHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
KTTVELLPVNGEFSLDDLQPWHPFGVDSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
IKTEEISEVKMDAEFGHDSGFEVRHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
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| BDBM155395 |
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| n/a |
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| Name | BDBM155395 |
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| Synonyms: | US9006283, 5 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H20F3N3O4 |
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| Mol. Mass. | 387.3536 |
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| SMILES | COc1ccccc1NC(=O)C(=O)N1N=C(CC(C)C)CC1(O)C(F)(F)F |t:15| |
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| Structure | 
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