| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Ligand | BDBM155485 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Assay |
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| pH | 8±n/a |
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| IC50 | 48±n/a nM |
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| Comments | extracted |
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| Citation |  Thunuguntla, SS; Subramanya, H; Kunnam, SR; Sanivaru Vijay, SR; Bingi, C; Kusanur, R; Schwarz, M; Arlt, M Dihydroorotate dehydrogenase inhibitors US Patent US9006454 Publication Date 4/14/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 42881.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q02127 |
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| Residue: | 395 |
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| Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
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| BDBM155485 |
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| n/a |
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| Name | BDBM155485 |
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| Synonyms: | US9006454, I127 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H18F4N2O3 |
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| Mol. Mass. | 506.4477 |
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| SMILES | Cc1cc(C(O)=O)c2nc([nH]c2c1)-c1c(F)c(F)c(-c2ccc(OCc3ccccc3)cc2)c(F)c1F |
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| Structure | 
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