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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | RAF proto-oncogene serine/threonine-protein kinase | ||
| Ligand | BDBM158481 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ADP-Glo Kinase Assay | ||
| pH | 7.5±n/a | ||
| IC50 | >10000±n/a nM | ||
| Comments | extracted | ||
| Citation |  Hammock, BD; Hwang, SH; Wecksler, AT; Morisseau, C Sorafenib derivatives as sEH inhibitors US Patent US9029401 Publication Date 5/12/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| RAF proto-oncogene serine/threonine-protein kinase | |||
| Name: | RAF proto-oncogene serine/threonine-protein kinase | ||
| Synonyms: | C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase RAF | Serine/threonine-protein kinase C-Raf | cRaf | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 73082.52 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P04049 | ||
| Residue: | 648 | ||
| Sequence: |
| ||
| BDBM158481 | |||
| n/a | |||
| Name | BDBM158481 | ||
| Synonyms: | US9029401, 1728 (t-TUCB) | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H21F3N2O5 | ||
| Mol. Mass. | 438.397 | ||
| SMILES | OC(=O)c1ccc(O[C@H]2CC[C@@H](CC2)NC(=O)Nc2ccc(OC(F)(F)F)cc2)cc1 |r,wU:8.7,wD:11.14,(10,,;8.67,-.77,;8.67,-2.31,;7.34,,;6,-.77,;4.67,,;4.67,1.54,;3.33,2.31,;2,1.54,;2,,;.67,-.77,;-.67,,;-.67,1.54,;.67,2.31,;-2,-.77,;-3.33,,;-3.33,1.54,;-4.67,-.77,;-6,,;-6,1.54,;-7.34,2.31,;-8.67,1.54,;-10,2.31,;-10,3.85,;-10,5.39,;-8.67,4.62,;-11.34,4.62,;-8.67,,;-7.34,-.77,;6,2.31,;7.34,1.54,)| | ||
| Structure | 
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