Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase B-raf [V600E] | ||
| Ligand | BDBM158490 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ADP-Glo Kinase Assay | ||
| pH | 7.5±n/a | ||
| IC50 | >10000±n/a nM | ||
| Comments | extracted | ||
| Citation |  Hammock, BD; Hwang, SH; Wecksler, AT; Morisseau, C Sorafenib derivatives as sEH inhibitors US Patent US9029401 Publication Date 5/12/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase B-raf [V600E] | |||
| Name: | Serine/threonine-protein kinase B-raf [V600E] | ||
| Synonyms: | B-RAF V600E | B-Raf (V600E) | B-Raf Protein Kinase Mutant (V600E) | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF (V600E) | BRAF mutant V600E | BRAF1 | BRAF_HUMAN | P15056 | Protein mono-ADP-ribosyltransferase (PARP3) | RAF serine/threonine protein kinase (V600E) | RAFB1 | Serine/threonine-protein kinase B-raf (V600E) | Serine/threonine-protein kinase B-raf (V600E) | Serine/threonine-protein kinase B-raf [V600E] | V-RAF murine sarcoma viral oncogene homologue B1 mutant (BRAF V600E) | ||
| Type: | n/a | ||
| Mol. Mass.: | 84474.98 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P15056 V600E | ||
| Residue: | 766 | ||
| Sequence: |
| ||
| BDBM158490 | |||
| n/a | |||
| Name | BDBM158490 | ||
| Synonyms: | US9029401, 2288 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H18ClF6N3O2 | ||
| Mol. Mass. | 481.819 | ||
| SMILES | FC(F)(F)c1ccc(O[C@H]2CC[C@@H](CC2)NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)nc1 |r,wU:9.8,wD:12.15,(10.71,-1.64,;9.39,-.86,;8.6,-2.18,;10.17,.47,;8.06,-.07,;6.67,-.77,;5.33,,;5.33,1.54,;4,2.31,;2.67,1.54,;2.67,,;1.33,-.77,;;,1.54,;1.33,2.31,;-1.33,-.77,;-2.67,,;-2.67,1.54,;-4,-.77,;-5.33,,;-5.33,1.54,;-6.67,2.31,;-8,1.54,;-9.34,2.31,;-8,,;-6.67,-.77,;-9.34,-.77,;-10.67,,;-9.34,-2.31,;-10.67,-1.54,;6.67,2.31,;8,1.54,)| | ||
| Structure | 
| ||