| Reaction Details |
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 | Report a problem with these data |
| Target | Mineralocorticoid receptor |
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| Ligand | BDBM158520 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Receptor Binding Assay |
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| IC50 | 66±n/a nM |
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| Citation |  Klar, U; Kuhnke, J; Bohlmann, R; Hübner, J; Ring, S; Frenzel, T; Menges, F; Borden, S; Muhn, HP; Prelle, K 17-(1′propenyl)-17-3′-oxidoestra-4-en-3-one derivative, use thereof, and medicament containing said derivative US Patent US9034856 Publication Date 5/19/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mineralocorticoid receptor |
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| Name: | Mineralocorticoid receptor |
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| Synonyms: | MCR | MCR_HUMAN | MLR | MR | NR3C2 | Nuclear receptor subfamily 3 group C member 2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 107076.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08235 |
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| Residue: | 984 |
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| Sequence: | METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNST
QGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYE
QQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAV
VKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPN
VENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSP
ANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVP
SPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSD
SSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGF
DGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSAR
DQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPS
KICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRL
QKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEEGTTYIAPAKEPSVN
TALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQV
VKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKM
HQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYI
KELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAML
VEIISDQLPKVESGNAKPLYFHRK
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| BDBM158520 |
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| n/a |
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| Name | BDBM158520 |
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| Synonyms: | US9034856, 8 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H28O2 |
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| Mol. Mass. | 324.4565 |
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| SMILES | CC[C@]12CC[C@@H]3[C@H]4CCC(=O)C=C4C=C[C@H]3[C@@H]1CC[C@]21OCC=C1 |r,c:11,14,26| |
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| Structure | 
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