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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase kinase kinase 14 | ||
| Ligand | BDBM158724 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| pH | 7.2±n/a | ||
| Ki | 0.5±n/a nM | ||
| Comments | extracted | ||
| Citation |  Staben, S; Castanedo, G; Montalbetti, CA; Feng, J Tricyclic compounds and methods of use therefor US Patent US9034866 Publication Date 5/19/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase kinase kinase 14 | |||
| Name: | Mitogen-activated protein kinase kinase kinase 14 | ||
| Synonyms: | HsNIK | M3K14_HUMAN | MAP3K14 | NF-kappa-beta-inducing kinase | NF-kappa-beta-inducing kinase (NF-kB) | NIK | Serine/threonine-protein kinase NIK | ||
| Type: | Protein | ||
| Mol. Mass.: | 104059.50 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q99558 | ||
| Residue: | 947 | ||
| Sequence: |
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| BDBM158724 | |||
| n/a | |||
| Name | BDBM158724 | ||
| Synonyms: | US9034866, 199 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H19F3N4O3 | ||
| Mol. Mass. | 456.4172 | ||
| SMILES | Cc1cc(no1)[C@](C)(O)C#Cc1ccc2C3CC(C3)n3c(nc(C(N)=O)c3C(F)(F)F)-c2c1 |r,wU:6.8,wD:6.7,(9.15,.72,;7.82,-.05,;6.57,.86,;5.32,-.05,;5.8,-1.51,;7.34,-1.51,;3.99,.72,;5.32,1.49,;3.99,2.26,;2.66,-.05,;1.32,-.82,;-.01,-1.59,;-.01,-3.13,;-1.34,-3.9,;-2.68,-3.13,;-3.88,-4.09,;-5.38,-3.75,;-6.05,-2.36,;-4.44,-2.67,;-5.38,-.97,;-3.88,-.63,;-3.74,.91,;-5.16,1.51,;-5.56,3,;-4.47,4.09,;-7.05,3.4,;-6.17,.35,;-7.66,.75,;-8.75,-.34,;-8.06,2.24,;-9.15,1.15,;-2.68,-1.59,;-1.34,-.82,)| | ||
| Structure | 
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