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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase kinase kinase 14 | ||
| Ligand | BDBM158798 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| pH | 7.2±n/a | ||
| Ki | 0.12±n/a nM | ||
| Comments | extracted | ||
| Citation |  Staben, S; Castanedo, G; Montalbetti, CA; Feng, J Tricyclic compounds and methods of use therefor US Patent US9034866 Publication Date 5/19/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase kinase kinase 14 | |||
| Name: | Mitogen-activated protein kinase kinase kinase 14 | ||
| Synonyms: | HsNIK | M3K14_HUMAN | MAP3K14 | NF-kappa-beta-inducing kinase | NF-kappa-beta-inducing kinase (NF-kB) | NIK | Serine/threonine-protein kinase NIK | ||
| Type: | Protein | ||
| Mol. Mass.: | 104059.50 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q99558 | ||
| Residue: | 947 | ||
| Sequence: |
| ||
| BDBM158798 | |||
| n/a | |||
| Name | BDBM158798 | ||
| Synonyms: | US9034866, 273 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H23FN4O3 | ||
| Mol. Mass. | 422.4521 | ||
| SMILES | CNC(=O)c1c(nc2-c3cc(C#CC4(O)CCCC4)c(F)cc3C3CC(C3)n12)C(N)=O |(-8.37,-.05,;-6.88,-.45,;-5.79,.64,;-6.19,2.13,;-4.3,.24,;-3.4,1.49,;-1.93,1.01,;-1.93,-.53,;-.67,-1.57,;.66,-.8,;1.99,-1.57,;3.33,-.8,;4.66,-.03,;6,.74,;4.66,1.51,;7.46,.27,;8.37,1.51,;7.46,2.76,;6,2.28,;1.99,-3.11,;3.33,-3.88,;.66,-3.88,;-.67,-3.11,;-1.88,-4.07,;-3.38,-3.72,;-4.05,-2.34,;-2.54,-2.6,;-3.4,-1,;-3.79,2.98,;-5.28,3.38,;-2.71,4.07,)| | ||
| Structure | 
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