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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase kinase kinase 14 | ||
| Ligand | BDBM158808 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| pH | 7.2±n/a | ||
| Ki | 0.16±n/a nM | ||
| Comments | extracted | ||
| Citation |  Staben, S; Castanedo, G; Montalbetti, CA; Feng, J Tricyclic compounds and methods of use therefor US Patent US9034866 Publication Date 5/19/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase kinase kinase 14 | |||
| Name: | Mitogen-activated protein kinase kinase kinase 14 | ||
| Synonyms: | HsNIK | M3K14_HUMAN | MAP3K14 | NF-kappa-beta-inducing kinase | NF-kappa-beta-inducing kinase (NF-kB) | NIK | Serine/threonine-protein kinase NIK | ||
| Type: | Protein | ||
| Mol. Mass.: | 104059.50 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q99558 | ||
| Residue: | 947 | ||
| Sequence: |
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| BDBM158808 | |||
| n/a | |||
| Name | BDBM158808 | ||
| Synonyms: | US9034866, 283 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H20FN5O2 | ||
| Mol. Mass. | 417.4356 | ||
| SMILES | Cn1c(nc-2c1C1CC(C1)c1cc(F)c(cc-21)C#C[C@@](C)(O)c1ncccn1)C(N)=O |r,wU:19.23,wD:19.24,(-6.49,.12,;-5,-.28,;-3.99,.88,;-2.58,.28,;-2.71,-1.25,;-4.22,-1.6,;-4.88,-2.98,;-4.22,-4.37,;-2.71,-4.72,;-3.38,-3.31,;-1.51,-3.75,;-.18,-4.52,;1.16,-3.75,;2.49,-4.52,;1.16,-2.21,;-.18,-1.44,;-1.51,-2.21,;2.49,-1.44,;3.82,-.67,;5.16,.1,;5.93,-1.24,;6.49,-.67,;5.16,1.64,;6.49,2.41,;6.49,3.95,;5.16,4.72,;3.82,3.95,;3.82,2.41,;-4.39,2.37,;-3.3,3.46,;-5.88,2.77,)| | ||
| Structure | 
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