Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Mitogen-activated protein kinase kinase kinase 14 | ||
Ligand | BDBM158886 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibition Assay | ||
pH | 7.2±n/a | ||
Ki | 0.2±n/a nM | ||
Comments | extracted | ||
Citation | Staben, S; Castanedo, G; Montalbetti, CA; Feng, J Tricyclic compounds and methods of use therefor US Patent US9034866 Publication Date 5/19/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Mitogen-activated protein kinase kinase kinase 14 | |||
Name: | Mitogen-activated protein kinase kinase kinase 14 | ||
Synonyms: | HsNIK | M3K14_HUMAN | MAP3K14 | NF-kappa-beta-inducing kinase | NF-kappa-beta-inducing kinase (NF-kB) | NIK | Serine/threonine-protein kinase NIK | ||
Type: | Protein | ||
Mol. Mass.: | 104059.50 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q99558 | ||
Residue: | 947 | ||
Sequence: |
| ||
BDBM158886 | |||
n/a | |||
Name | BDBM158886 | ||
Synonyms: | US9034866, 361 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H22N4O3 | ||
Mol. Mass. | 390.4351 | ||
SMILES | CNC(=O)c1c(nc2-c3cc(ccc3C3CC(C3)n12)C#CC1(O)CCC1)C(N)=O |(-8.06,.06,;-6.57,-.34,;-5.48,.75,;-5.88,2.24,;-3.99,.35,;-2.98,1.51,;-1.56,.91,;-1.7,-.63,;-.5,-1.59,;.84,-.82,;2.17,-1.59,;2.17,-3.13,;.84,-3.9,;-.5,-3.13,;-1.7,-4.09,;-3.2,-3.75,;-3.87,-2.36,;-2.31,-2.65,;-3.2,-.97,;3.5,-.82,;4.84,-.05,;6.17,.72,;4.84,1.49,;7.66,.32,;8.06,1.81,;6.57,2.21,;-3.38,3,;-2.29,4.09,;-4.87,3.4,)| | ||
Structure |