Reaction Details | |||
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Target | Mitogen-activated protein kinase kinase kinase 14 | ||
Ligand | BDBM158889 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibition Assay | ||
pH | 7.2±n/a | ||
Ki | 0.53±n/a nM | ||
Comments | extracted | ||
Citation | Staben, S; Castanedo, G; Montalbetti, CA; Feng, J Tricyclic compounds and methods of use therefor US Patent US9034866 Publication Date 5/19/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Mitogen-activated protein kinase kinase kinase 14 | |||
Name: | Mitogen-activated protein kinase kinase kinase 14 | ||
Synonyms: | HsNIK | M3K14_HUMAN | MAP3K14 | NF-kappa-beta-inducing kinase | NF-kappa-beta-inducing kinase (NF-kB) | NIK | Serine/threonine-protein kinase NIK | ||
Type: | Protein | ||
Mol. Mass.: | 104059.50 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q99558 | ||
Residue: | 947 | ||
Sequence: |
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BDBM158889 | |||
n/a | |||
Name | BDBM158889 | ||
Synonyms: | US9034866, 364 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H18FN3O2 | ||
Mol. Mass. | 351.3742 | ||
SMILES | NC(=O)c1cn2C3CC(C3)c3cc(F)c(cc3-c2n1)C#CC1(O)CCC1 |(-3.88,4.09,;-4.97,3,;-6.46,3.4,;-4.58,1.51,;-5.59,.35,;-4.8,-.97,;-5.47,-2.36,;-4.8,-3.75,;-3.3,-4.09,;-3.85,-2.36,;-2.09,-3.13,;-.76,-3.9,;.57,-3.13,;1.91,-3.9,;.57,-1.59,;-.76,-.82,;-2.09,-1.59,;-3.3,-.63,;-3.16,.91,;1.91,-.82,;3.24,-.05,;4.58,.72,;3.24,1.49,;6.06,.32,;6.46,1.81,;4.97,2.21,)| | ||
Structure |