| Reaction Details |
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 | Report a problem with these data |
| Target | Glutaminyl-peptide cyclotransferase |
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| Ligand | BDBM159348 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 8±n/a |
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| Temperature | 303.15±n/a K |
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| Ki | 11.6±n/a nM |
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| IC50 | 92.3±n/a nM |
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| Comments | extracted |
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| Citation |  Buchholz, M; Heiser, U Inhibitors of glutaminyl cyclase US Patent US9034907 Publication Date 5/19/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutaminyl-peptide cyclotransferase |
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| Name: | Glutaminyl-peptide cyclotransferase |
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| Synonyms: | Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 40877.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16769 |
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| Residue: | 361 |
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| Sequence: | MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGT
SISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSF
SNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLS
LKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHG
MDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYG
GVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLH
L
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| BDBM159348 |
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| n/a |
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| Name | BDBM159348 |
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| Synonyms: | US9034907, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H16N4OS |
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| Mol. Mass. | 300.379 |
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| SMILES | Cc1cncn1CCCn1c(=S)[nH]c2ccccc2c1=O |
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| Structure | 
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