Ki Summary

Reaction Details

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Target

C-C chemokine receptor-like 2

Ligand

BDBM163395

Substrate/Competitor

n/a

Meas. Tech.

Receptor Binding Assay

IC50

64±n/a nM

Citation

Lanter, JC; Markotan, TP; Subasinghe, N; Sui, Z Cyclohexyl-azetidinyl antagonists of CCR2 US Patent US9062048 Publication Date 6/23/2015

More Info.:

Get all data from this article, Assay Method

C-C chemokine receptor-like 2

Name:

C-C chemokine receptor-like 2

Synonyms:

Type:

Protein

Mol. Mass.:

39518.98

Organism:

Homo sapiens (Human)

Description:

O00421

Residue:

344

Sequence:

MANYTLAPEDEYDVLIEGELESDEAEQCDKYDAQALSAQLVPSLCSAVFVIGVLDNLLVV
LILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAGGDPMCKILIGLYFVGLYSETFF
NCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYK
CAFSRTPFLPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFKLV
FAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLY
AFLDGTFSKYLCRCFHLRSNTPLQPRGQSAQGTSREEPDHSTEV

BDBM163395

n/a

Name

BDBM163395

Synonyms:

US9062048, 52

Type

Small organic molecule

Emp. Form.

C24H31F3N6O2

Mol. Mass.

492.5371

SMILES

FC(F)(F)c1ccc2ncnc(NCC(=O)NC3CN(C3)[C@H]3CC[C@H](CC3)N3CCCCO3)c2c1 |r,wU:21.21,24.28,(10.28,-1.54,;8.95,-.77,;8.95,.77,;10.28,,;7.61,-1.54,;7.61,-3.08,;6.28,-3.85,;4.94,-3.08,;3.61,-3.85,;2.28,-3.08,;2.28,-1.54,;3.61,-.77,;3.61,.77,;2.28,1.54,;2.28,3.08,;3.61,3.85,;.94,3.85,;-.39,3.08,;-1.88,3.48,;-2.28,1.99,;-.79,1.59,;-3.61,1.22,;-3.61,-.32,;-4.94,-1.09,;-6.28,-.32,;-6.28,1.22,;-4.94,1.99,;-7.61,-1.09,;-7.61,-2.63,;-8.95,-3.4,;-10.28,-2.63,;-10.28,-1.09,;-8.95,-.32,;4.94,-1.54,;6.28,-.77,)|

Structure