Ki Summary

Reaction Details

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Target

C-C chemokine receptor-like 2

Ligand

BDBM163405

Substrate/Competitor

n/a

Meas. Tech.

Receptor Binding Assay

IC50

550±n/a nM

Citation

Lanter, JC; Markotan, TP; Subasinghe, N; Sui, Z Cyclohexyl-azetidinyl antagonists of CCR2 US Patent US9062048 Publication Date 6/23/2015

More Info.:

Get all data from this article, Assay Method

C-C chemokine receptor-like 2

Name:

C-C chemokine receptor-like 2

Synonyms:

Type:

Protein

Mol. Mass.:

39518.98

Organism:

Homo sapiens (Human)

Description:

O00421

Residue:

344

Sequence:

MANYTLAPEDEYDVLIEGELESDEAEQCDKYDAQALSAQLVPSLCSAVFVIGVLDNLLVV
LILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAGGDPMCKILIGLYFVGLYSETFF
NCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYK
CAFSRTPFLPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFKLV
FAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLY
AFLDGTFSKYLCRCFHLRSNTPLQPRGQSAQGTSREEPDHSTEV

BDBM163405

n/a

Name

BDBM163405

Synonyms:

US9062048, 56

Type

Small organic molecule

Emp. Form.

C25H31F3N6O2

Mol. Mass.

504.5478

SMILES

FC(F)(F)c1ccc2ncnc(NCC(=O)NC3CN(C3)[C@H]3CC[C@H](CC3)N3CCCCC3=O)c2c1 |r,wU:24.28,21.21,(10.28,2.92,;8.94,2.15,;7.61,2.92,;8.94,3.69,;8.94,.61,;10.28,-.16,;10.28,-1.7,;8.94,-2.47,;8.94,-4.01,;7.61,-4.78,;6.28,-4.01,;6.28,-2.47,;4.94,-1.7,;3.61,-2.47,;2.28,-1.7,;2.28,-.16,;.94,-2.47,;-.39,-1.7,;-1.88,-2.1,;-2.28,-.61,;-.79,-.21,;-3.61,.16,;-4.94,-.61,;-6.28,.16,;-6.28,1.7,;-4.94,2.47,;-3.61,1.7,;-7.61,2.47,;-7.61,4.01,;-8.94,4.78,;-10.28,4.01,;-10.28,2.47,;-8.94,1.7,;-8.94,.16,;7.61,-1.7,;7.61,-.16,)|

Structure