Ki Summary

Reaction Details

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Target

C-C chemokine receptor-like 2

Ligand

BDBM163446

Substrate/Competitor

n/a

Meas. Tech.

Receptor Binding Assay

IC50

55±n/a nM

Citation

Lanter, JC; Markotan, TP; Subasinghe, N; Sui, Z Cyclohexyl-azetidinyl antagonists of CCR2 US Patent US9062048 Publication Date 6/23/2015

More Info.:

Get all data from this article, Assay Method

C-C chemokine receptor-like 2

Name:

C-C chemokine receptor-like 2

Synonyms:

Type:

Protein

Mol. Mass.:

39518.98

Organism:

Homo sapiens (Human)

Description:

O00421

Residue:

344

Sequence:

MANYTLAPEDEYDVLIEGELESDEAEQCDKYDAQALSAQLVPSLCSAVFVIGVLDNLLVV
LILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAGGDPMCKILIGLYFVGLYSETFF
NCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYK
CAFSRTPFLPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFKLV
FAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLY
AFLDGTFSKYLCRCFHLRSNTPLQPRGQSAQGTSREEPDHSTEV

BDBM163446

n/a

Name

BDBM163446

Synonyms:

US9062048, 73

Type

Small organic molecule

Emp. Form.

C27H30F3N5O2

Mol. Mass.

513.5546

SMILES

OCc1ccccc1C1CC[C@@H](CC1)N1CC(C1)NC(=O)CNc1ncnc2ccc(cc12)C(F)(F)F |r,wU:11.15,(-5.71,-.67,;-7.25,-.67,;-8.02,.67,;-9.56,.67,;-10.33,2,;-9.56,3.33,;-8.02,3.33,;-7.25,2,;-5.71,2,;-4.94,.67,;-3.4,.67,;-2.63,2,;-3.4,3.33,;-4.94,3.33,;-1.09,2,;,.91,;1.09,2,;,3.09,;2.63,2,;3.4,.67,;2.63,-.67,;4.94,.67,;5.71,2,;7.25,2,;8.02,3.33,;9.56,3.33,;10.33,2,;9.56,.67,;10.33,-.67,;9.56,-2,;8.02,-2,;7.25,-.67,;8.02,.67,;7.25,-3.33,;6.48,-4.67,;5.71,-3.33,;8.02,-4.67,)|

Structure