Ki Summary

Reaction Details

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Target

C-C chemokine receptor-like 2

Ligand

BDBM163466

Substrate/Competitor

n/a

Meas. Tech.

Receptor Binding Assay

IC50

28±n/a nM

Citation

Lanter, JC; Markotan, TP; Subasinghe, N; Sui, Z Cyclohexyl-azetidinyl antagonists of CCR2 US Patent US9062048 Publication Date 6/23/2015

More Info.:

Get all data from this article, Assay Method

C-C chemokine receptor-like 2

Name:

C-C chemokine receptor-like 2

Synonyms:

Type:

Protein

Mol. Mass.:

39518.98

Organism:

Homo sapiens (Human)

Description:

O00421

Residue:

344

Sequence:

MANYTLAPEDEYDVLIEGELESDEAEQCDKYDAQALSAQLVPSLCSAVFVIGVLDNLLVV
LILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAGGDPMCKILIGLYFVGLYSETFF
NCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYK
CAFSRTPFLPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFKLV
FAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLY
AFLDGTFSKYLCRCFHLRSNTPLQPRGQSAQGTSREEPDHSTEV

BDBM163466

n/a

Name

BDBM163466

Synonyms:

US9062048, 95

Type

Small organic molecule

Emp. Form.

C23H26F3N5O2

Mol. Mass.

461.48

SMILES

OC(C#C)[C@H]1CC[C@H](CC1)N1CC(C1)NC(=O)CNc1ncnc2ccc(cc12)C(F)(F)F |r,wU:7.10,4.3,(-9.61,-.16,;-8.28,-.93,;-8.28,-2.47,;-8.28,-4.01,;-6.94,-.16,;-6.94,1.38,;-5.61,2.15,;-4.28,1.38,;-4.28,-.16,;-5.61,-.93,;-2.94,2.15,;-2.55,3.64,;-1.06,3.24,;-1.46,1.75,;.28,4.01,;1.61,3.24,;2.94,4.01,;1.61,1.7,;2.94,.93,;2.94,-.61,;1.61,-1.38,;1.61,-2.92,;2.94,-3.69,;4.28,-2.92,;5.61,-3.69,;6.94,-2.92,;6.94,-1.38,;5.61,-.61,;4.28,-1.38,;8.28,-.61,;9.61,.16,;9.05,-1.94,;7.51,.72,)|

Structure