Ki Summary

Reaction Details

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Target

C-C chemokine receptor-like 2

Ligand

BDBM163503

Substrate/Competitor

n/a

Meas. Tech.

Receptor Binding Assay

IC50

1000±n/a nM

Citation

Lanter, JC; Markotan, TP; Subasinghe, N; Sui, Z Cyclohexyl-azetidinyl antagonists of CCR2 US Patent US9062048 Publication Date 6/23/2015

More Info.:

Get all data from this article, Assay Method

C-C chemokine receptor-like 2

Name:

C-C chemokine receptor-like 2

Synonyms:

Type:

Protein

Mol. Mass.:

39518.98

Organism:

Homo sapiens (Human)

Description:

O00421

Residue:

344

Sequence:

MANYTLAPEDEYDVLIEGELESDEAEQCDKYDAQALSAQLVPSLCSAVFVIGVLDNLLVV
LILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAGGDPMCKILIGLYFVGLYSETFF
NCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYK
CAFSRTPFLPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFKLV
FAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLY
AFLDGTFSKYLCRCFHLRSNTPLQPRGQSAQGTSREEPDHSTEV

BDBM163503

n/a

Name

BDBM163503

Synonyms:

US9062048, 130

Type

Small organic molecule

Emp. Form.

C25H31F3N6O2

Mol. Mass.

504.5478

SMILES

FC(F)(F)c1ccc2ncnc(NCC(=O)NC3CN(C3)C3CC[C@@H](CC3)C(=O)N3CCCC3)c2c1 |r,wU:24.28,(10.71,-0,;9.38,-.77,;10.15,-2.1,;8.61,.56,;8.05,-1.54,;8.05,-3.08,;6.71,-3.85,;5.38,-3.08,;4.05,-3.85,;2.71,-3.08,;2.71,-1.54,;4.05,-.77,;4.05,.77,;2.71,1.54,;2.71,3.08,;4.05,3.85,;1.38,3.85,;.04,3.08,;-1.44,3.48,;-1.84,1.99,;-.35,1.59,;-3.18,1.22,;-4.51,1.99,;-5.84,1.22,;-5.84,-.32,;-4.51,-1.09,;-3.18,-.32,;-7.18,-1.09,;-7.18,-2.63,;-8.51,-.32,;-8.51,1.22,;-9.97,1.7,;-10.88,.45,;-9.97,-.79,;5.38,-1.54,;6.71,-.77,)|

Structure