Ki Summary

Reaction Details

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Target

C-C chemokine receptor-like 2

Ligand

BDBM163589

Substrate/Competitor

n/a

Meas. Tech.

Receptor Binding Assay

IC50

35±n/a nM

Citation

Lanter, JC; Markotan, TP; Subasinghe, N; Sui, Z Cyclohexyl-azetidinyl antagonists of CCR2 US Patent US9062048 Publication Date 6/23/2015

More Info.:

Get all data from this article, Assay Method

C-C chemokine receptor-like 2

Name:

C-C chemokine receptor-like 2

Synonyms:

Type:

Protein

Mol. Mass.:

39518.98

Organism:

Homo sapiens (Human)

Description:

O00421

Residue:

344

Sequence:

MANYTLAPEDEYDVLIEGELESDEAEQCDKYDAQALSAQLVPSLCSAVFVIGVLDNLLVV
LILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAGGDPMCKILIGLYFVGLYSETFF
NCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYK
CAFSRTPFLPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFKLV
FAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLY
AFLDGTFSKYLCRCFHLRSNTPLQPRGQSAQGTSREEPDHSTEV

BDBM163589

n/a

Name

BDBM163589

Synonyms:

US9062048, 169

Type

Small organic molecule

Emp. Form.

C25H33F3N4O2

Mol. Mass.

478.5503

SMILES

CC(C)C(O)[C@H]1CC[C@H](CC1)N1CC(C1)NC(=O)CNc1nccc2ccc(cc12)C(F)(F)F |r,wU:5.4,8.11,(-9.94,-4,;-8.4,-4,;-7.63,-5.33,;-7.63,-2.67,;-8.4,-1.33,;-6.09,-2.67,;-5.32,-1.33,;-3.78,-1.33,;-3.01,-2.67,;-3.78,-4,;-5.32,-4,;-1.47,-2.67,;-.38,-3.76,;.7,-2.67,;-.38,-1.58,;2.24,-2.67,;3.01,-1.33,;2.24,,;4.55,-1.33,;5.32,,;6.86,,;7.63,-1.33,;9.17,-1.33,;9.94,,;9.17,1.33,;9.94,2.67,;9.17,4,;7.63,4,;6.86,2.67,;7.63,1.33,;6.86,5.33,;6.09,6.67,;5.38,4.94,;7.63,6.67,)|

Structure