| Reaction Details |
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 | Report a problem with these data |
| Target | Leucine--tRNA ligase [A132I,E138V,K510E,I952T] |
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| Ligand | BDBM163674 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Isothermal Titration Calorimetry (ITC) |
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| pH | 8±0 |
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| Temperature | 298.15±0 K |
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| Kd | 2.1e+4± 3e+3 nM |
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| Citation |  Zhao, H; Palencia, A; Seiradake, E; Ghaemi, Z; Cusack, S; Luthey-Schulten, Z; Martinis, S Analysis of the Resistance Mechanism of a Benzoxaborole Inhibitor Reveals Insight into the Leucyl-tRNA Synthetase Editing Mechanism. ACS Chem Biol10:2277-85 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Leucine--tRNA ligase [A132I,E138V,K510E,I952T] |
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| Name: | Leucine--tRNA ligase [A132I,E138V,K510E,I952T] |
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| Synonyms: | Leucyl-tRNA synthetase K510E mutant (K510E) |
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| Type: | Protein |
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| Mol. Mass.: | 125396.76 |
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| Organism: | Candida albicans (Ascomycetes) |
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| Description: | A0A1D8PS12[A132I,E138V,K510E,I952T] |
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| Residue: | 1097 |
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| Sequence: | MSGPVTFEKTFRRDALIDIEKKYQKVWAEEKVFEVDAPTFEECPIEDVEQVQEAHPKFFA
TMAYPYMNGVLHAGHAFTLSKVEFATGFQRMNGKRALFPLGFHCTGMPIKAAADKIKREV
ELFGSDFSKAPIDDEDAVESQQPAKTETKREDVTKFSSKKSKAAAKQGRAKFQYEIMMQL
GIPREEVAKFANTDYWLEFFPPLCQKDVTAFGARVDWRRSMITTDANPYYDAFVRWQINR
LRDVGKIKFGERYTIYSEKDGQACLDHDRQSGEGVGPQEYVGIKIRLTDVAPQAQELFKK
ENLDVKENKVYLVAATLRPETMYGQTCCFVSPKIDYGVFDAGNGDYFITTERAFKNMSFQ
NLTPKRGYYKPLFIINGKTLIGSRIDAPYAVNKNLRVLPMETVLATKGTGVVTCVPSDSP
DDFVTTRDLANKPEYYGIEKDWVQTDIVPIVHTEKYGDKCAEFLVNDLKIQSPKDSVQLA
NAKELAYKEGFYNGTMLIGKYKGDKVEDAEPKVKQDLIDEGLAFVYNEPESQVISRSGDD
CCVSLEDQWYIDYGEEAWLGEALECLKNMETYSKETRHGFEGVLAWMKNWAVTRKFGLGT
KLPWDPQYLVESLSDSTVYMAYYTIDRFLHSDYYGKKAGKFDIKPEQMTDEVFDYIFTRR
DDVETDIPKEQLKEMRREFEYFYPLDVRVSGKDLIPNHLTFFIYTHVALFPKRFWPRGVR
ANGHLLLNNAKMSKSTGNFMTLEQIIEKFGADASRIAMADAGDTVEDANFDEANANAAIL
RLTTLKDWCEEEVKNQDKLRTGDYDSFFDAAFENEMNDLIEKTYQQYTLSNYKQALKSGL
FDFQIARDIYRESVNTTGIGMHKDLVLKYIEYQALMLAPIAPHFAEYLYREVLGKNGSVQ
TSKFPRASKPVSKAILDASEYVRSLTRSIREAEGQALKKKKGKSDVDGSKPTSLTVLVSN
TFPEWQDNYIELVRELFEQNKLDDNNVIRQKVGKDMKRGMPYIHQIKTRLATEDADTVFN
RKLTFDEIDTLKNVVEIVKNAPYSLKVEKLEILSFNNGETKGKNIISGEDNIELNFKGKI
MENAVPGEPGIFIKNVE
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| BDBM163674 |
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| n/a |
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| Name | BDBM163674 |
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| Synonyms: | AN2690-AMP |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18BFN5O4 |
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| Mol. Mass. | 398.177 |
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| SMILES | CC[C@H]1O[C@H]([C@H]2O[B-]3(OCc4cc(F)ccc34)OC12)n1cnc2c(N)ncnc12 |r| |
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| Structure | 
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