| Reaction Details |
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 | Report a problem with these data |
| Target | Rhomboid protease GluP [F193S,L370F,L379S,R499W] |
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| Ligand | BDBM165194 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Activity-based Protein Profiling (ABPP) |
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| pH | 7.4±0 |
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| Temperature | 310.15±0 K |
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| IC50 | 2.5e+4± 6e+3 nM |
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| Citation |  Wolf, EV; Zeissler, A; Verhelst, SH Inhibitor Fingerprinting of Rhomboid Proteases by Activity-Based Protein Profiling Reveals Inhibitor Selectivity and Rhomboid Autoprocessing. ACS Chem Biol10:2325-33 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Rhomboid protease GluP [F193S,L370F,L379S,R499W] |
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| Name: | Rhomboid protease GluP [F193S,L370F,L379S,R499W] |
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| Synonyms: | GLUP_BACSU | Rhomboid protease (BsYqgP) | gluP | yqgP |
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| Type: | Protein |
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| Mol. Mass.: | 56433.35 |
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| Organism: | Bacillus subtilis (Firmicutes) |
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| Description: | P54493[F193S,L370F,L379S,R499W] |
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| Residue: | 507 |
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| Sequence: | MFLLEYTYWKIAAHLVNSGYGVIQAGESDEIWLEAPDKSSHDLVRLYKHDLDFRQEMVRD
IEEQAERVERVRHQLGRRRMKLLNVFFSTEAPVDDWEEIAKKTFEKGTVSVEPAIVRGTM
LRDDLQAVFPSFRTEDCSEEHASFENAQMARERFLSLVLKQEEQRKTEAAVFQNGKPTFT
YLFIALQILMFSLLEINGGSTNTETLVAFGAKENSLIAQGEWWRLLTPIVLHIGIAHLAF
NTLALWSVGTAVERMYGSGRFLLIYLAAGITGSIASFVFSPYPSAGASGAIFGCLGALLY
VALSNRKMFLRTIGTNIIVIIIINLGFGFAVSNIDNSGHIGGLIGGFFAAAALGLPKAGA
FGKRLLSAVFLIALAVGFSYYGLHSPSHQESALIQQASELYQEGKYEEVTELLNGEAAQK
DASADLLKILAVSDIQIGEYDQAVSLLERAVKKEPKDHASYYNLALLYAEKNELAQAEKA
IQTAVKLKPKEQRYKELQWQIENNKES
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| BDBM165194 |
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| n/a |
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| Name | BDBM165194 |
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| Synonyms: | 4‐Chloro‐7‐nitro‐3‐[(5‐phenylpentyl)oxy]isochromen‐1‐one (21) |
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| Type | Small organic molecule |
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| Emp. Form. | C20H18ClNO5 |
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| Mol. Mass. | 387.814 |
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| SMILES | [O-][N+](=O)c1ccc2c(Cl)c(OCCCCCc3ccccc3)oc(=O)c2c1 |
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| Structure | 
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