Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetRhomboid protease (MmRHBDL3)
LigandBDBM165194
Substrate/Competitorn/a
Meas. Tech.Activity-based Protein Profiling (ABPP)
pH7.4±0
Temperature310.15±0 K
IC50 2.4e+4± 3e+3 nM
Citation Wolf EVZeissler AVerhelst SH Inhibitor Fingerprinting of Rhomboid Proteases by Activity-Based Protein Profiling Reveals Inhibitor Selectivity and Rhomboid Autoprocessing. ACS Chem Biol 10:2325-33 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Rhomboid protease (MmRHBDL3)
Name:Rhomboid protease (MmRHBDL3)
Synonyms:Rhomboid-related protein 3
Type:Protein
Mol. Mass.:45272.26
Organism:Mus musculus (Mouse)
Description:n/a
Residue:404
Sequence:
MGEHPSPGPAVAACAEAERIEELEPEAEERLPAAPEDHWKVLFEKFDPGSTGYISTGKFR
SLLESHSSKLDPHKKEVLLALADSHADGQICYQDFVNLMSNKRSNSFRQAILQGNRRLSS
KALLEEKGLSLSQRLIRHVAYETLPREIDRKWYYDSYTCCPPPWFMITITLLEVALFLYN
GVLLDQFVLQVTHPRYLKNSLVYHPQLRAQAWRYVTYIFMHAGVEQLGLNVALQLLVGVP
LEMVHGATRIGLVYVAGVVAGSLAVSVADMTAPVVGSSGGVYALVSAHLANIVMNWSGMK
CQFKLLRMAVALICMSMEFGRAVWLRFHPSAYPPCPHPSFVAHLGGVAVGITLGVVVLRN
YEQRLQDQSLWWIFVTMYTIFVLFAVFWNIFAYTLLDLKLPPAP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM165194
n/a
NameBDBM165194
Synonyms:4‐Chloro‐7‐nitro‐3‐[(5‐phenylpentyl)oxy]isochromen‐1‐one (21)
TypeSmall organic molecule
Emp. Form.C20H18ClNO5
Mol. Mass.387.814
SMILES[O-][N+](=O)c1ccc2c(Cl)c(OCCCCCc3ccccc3)oc(=O)c2c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: