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TargetRenal Outer Medullary Potassium (ROMK)
LigandBDBM163800
Substrate/Competitorn/a
Meas. Tech.Electrophysiology Assay
pH7.4±n/a
IC50 60±n/a nM
Commentsextracted
Citation Pasternak ABlizzard TChobanian Hde Jesus RDing FDong SGude CKim DTang HWalsh SPio BJiang J Inhibitors of the renal outer medullary potassium channel US Patent  US9062070 Publication Date 6/23/2015
More Info.:Get all data from this article,  Assay Method
 
Renal Outer Medullary Potassium (ROMK)
Name:Renal Outer Medullary Potassium (ROMK)
Synonyms:ATP-regulated potassium channel ROM-K | ATP-sensitive inward rectifier potassium channel 1 | Inward rectifier K(+) channel Kir1.1 | KAB-1 | Kcnj1 | Potassium channel (ATP modulatory) | Potassium channel, inwardly rectifying subfamily J member 1 | Renal Outer Medullary Potassium (ROMK1) | Romk1 | The Renal Outer Medullary Potassium (ROMK) channel (Kir1.1)
Type:Enzyme
Mol. Mass.:44976.27
Organism:Rattus norvegicus (Rat)
Description:P35560
Residue:391
Sequence:
MGASERSVFRVLIRALTERMFKHLRRWFITHIFGRSRQRARLVSKEGRCNIEFGNVDAQS
RFIFFVDIWTTVLDLKWRYKMTVFITAFLGSWFLFGLLWYVVAYVHKDLPEFYPPDNRTP
CVENINGMTSAFLFSLETQVTIGYGFRFVTEQCATAIFLLIFQSILGVIINSFMCGAILA
KISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTITPEGE
TIILDQTNINFVVDAGNENLFFISPLTIYHIIDHNSPFFHMAAETLSQQDFELVVFLDGT
VESTSATCQVRTSYVPEEVLWGYRFVPIVSKTKEGKYRVDFHNFGKTVEVETPHCAMCLY
NEKDARARMKRGYDNPNFVLSEVDETDDTQM
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  Blast E-value cutoff:
BDBM163800
n/a
NameBDBM163800
Synonyms:US9062070, 55 | US9062070, 56
TypeSmall organic molecule
Emp. Form.C25H25N7O4
Mol. Mass.487.5105
SMILESO=C(C1CCc2cc(ncc12)-n1cnnn1)N1CCN2C[C@@H](OC[C@@H]2C1)c1ccc2C(=O)OCc2c1 |r|
Structure
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