| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen synthase kinase-3 alpha |
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| Ligand | BDBM164883 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Kinase Inhibition Assay |
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| pH | 7.5±n/a |
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| IC50 | 160±n/a nM |
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| Comments | extracted |
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| Citation |  Zeitlmann, L; Niestroj, A; Heiser, U Inhibitors of protein kinases US Patent US9067888 Publication Date 6/30/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Glycogen synthase kinase-3 alpha |
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| Name: | Glycogen synthase kinase-3 alpha |
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| Synonyms: | GSK-3 alpha | GSK3A | GSK3A_HUMAN | Glycogen synthase kinase 3 alpha (GSKalpha) | Glycogen synthase kinase-3 | Glycogen synthase kinase-3 alpha | Glycogen synthase kinase-3 alpha (GSK3 Alpha) | Glycogen synthase kinase-3 alpha (GSK3A) | Glycogen synthase kinase-3 alpha (GSK3alpha) |
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| Type: | Enzyme |
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| Mol. Mass.: | 50991.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49840 |
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| Residue: | 483 |
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| Sequence: | MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGV
GASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYT
DIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY
SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGV
CHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSS
IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK
AHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLP
PLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLT
NSS
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| BDBM164883 |
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| n/a |
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| Name | BDBM164883 |
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| Synonyms: | US9067888, 33 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24FN3O3 |
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| Mol. Mass. | 385.432 |
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| SMILES | COc1cc(F)ccc1-c1ccnc(NC(=O)[C@H]2CCC[C@H](C2)NC(C)=O)c1 |r| |
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| Structure | 
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