| Reaction Details |
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 | Report a problem with these data |
| Target | Interleukin-1 receptor-associated kinase 1 |
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| Ligand | BDBM164884 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Kinase Inhibition Assay |
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| pH | 7.5±n/a |
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| IC50 | >5000±n/a nM |
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| Comments | extracted |
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| Citation |  Zeitlmann, L; Niestroj, A; Heiser, U Inhibitors of protein kinases US Patent US9067888 Publication Date 6/30/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Interleukin-1 receptor-associated kinase 1 |
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| Name: | Interleukin-1 receptor-associated kinase 1 |
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| Synonyms: | IRAK | IRAK-1 | IRAK1 | IRAK1_HUMAN | Interleukin-1 receptor-associated kinase 1 (IRAK-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 76536.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51617 |
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| Residue: | 712 |
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| Sequence: | MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCE
RSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSS
IPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTK
PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR
LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL
HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFG
LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG
QRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDP
RPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPP
SPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALR
SWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQI
IINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS
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| BDBM164884 |
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| n/a |
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| Name | BDBM164884 |
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| Synonyms: | US9067888, 34 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22FN3O3 |
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| Mol. Mass. | 371.4054 |
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| SMILES | COc1cc(F)ccc1-c1ccnc(NC(=O)C2CCC(C2)NC(C)=O)c1 |
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| Structure | 
|
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