| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-secretase 1 |
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| Ligand | BDBM165909 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ELISA Assay |
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| IC50 | 3±n/a nM |
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| Citation |  Hilpert, H; Rogers-Evans, M; Rombach, D 1,4 thiazepines/sulfones as BACE1 and/or BACE2 inhibitors US Patent US9067924 Publication Date 6/30/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-secretase 1 |
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| Name: | Beta-secretase 1 |
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| Synonyms: | BACE1_MOUSE | Bace | Bace1 | Beta-secretase 1 | Beta-secretase 1 (BACE1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 55739.56 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P56818 |
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| Residue: | 501 |
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| Sequence: | MAPALHWLLLWVGSGMLPAQGTHLGIRLPLRSGLAGPPLGLRLPRETDEESEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGAGFPLNQTEALASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
RCLRCLRHQHDDFADDISLLK
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| BDBM165909 |
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| n/a |
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| Name | BDBM165909 |
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| Synonyms: | US9067924, 3 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18ClFN4O3S |
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| Mol. Mass. | 424.877 |
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| SMILES | C[C@]1(CCS(=O)(=O)CC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F |r,c:9| |
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| Structure | 
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