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TargetProteinase-activated receptor 1
LigandBDBM169626
Substrate/Competitorn/a
Meas. Tech.Binding Assay
pH7.5±n/a
Temperature298.15±n/a K
IC50 1100±n/a nM
Commentsextracted
Citation Heinelt, UWehner, VHerrmann, MSchoenafinger, KSteinhagen, HScheiper, B Triazolopyridazines as PAR1 inhibitors, production thereof, and use as medicaments US Patent US9079906 Publication Date 7/14/2015
More Info.:Get all data from this article,  Assay Method
 
Proteinase-activated receptor 1
Name:Proteinase-activated receptor 1
Synonyms:CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1)
Type:Protein
Mol. Mass.:47450.07
Organism:Homo sapiens (Human)
Description:P25116
Residue:425
Sequence:
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEE
KNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLN
IMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTA
AFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLK
EQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSS
AVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVS
SISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIY
KKLLT
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  Blast E-value cutoff:
BDBM169626
n/a
NameBDBM169626
Synonyms:US9079906, 26
TypeSmall organic molecule
Emp. Form.C26H35N5O3
Mol. Mass.465.5878
SMILESCCC(CC)Oc1ccc2nn(CC(=O)c3cc(OCC4CC4)cc(c3)C(C)(C)C)c(=N)n2n1
Structure
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