| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 7 |
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| Ligand | BDBM173371 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | FLIPR Assay |
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| pH | 7.4±n/a |
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| IC50 | 11±n/a nM |
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| Comments | extracted |
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| Citation |  Alcazar Vaca, MJ; Andres Gil, JI; Letavic, MA; Rudolph, DA; Shireman, BT; Stenne, BM; Ziff, JM P2X7 modulators US Patent US9096596 Publication Date 8/4/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 7 |
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| Name: | P2X purinoceptor 7 |
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| Synonyms: | ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor |
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| Type: | Protein |
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| Mol. Mass.: | 68602.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q99572 |
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| Residue: | 595 |
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| Sequence: | MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISS
VHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCP
EYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPA
LLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGD
NFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYK
ENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSS
NCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRS
LQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCG
SCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDS
TNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
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| BDBM173371 |
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| n/a |
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| Name | BDBM173371 |
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| Synonyms: | US10323032, Example 84 | US9096596, 84 | US9604982, Example 84 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H17Cl2N5O |
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| Mol. Mass. | 402.277 |
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| SMILES | C[C@@H]1Cc2c(CN1C(=O)c1ccc(Cl)cc1Cl)nc(C)nc2-c1ccn[nH]1 |r| |
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| Structure | 
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