Reaction Details |
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Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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Ligand | BDBM50345406 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibiton Assay |
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pH | 8±n/a |
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IC50 | 60±n/a nM |
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Comments | extracted |
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Citation | Rathod, PK; Floyd, D; Burrows, J; Marwaha, A; Gujjar, R; Coteron-Lopez, J; Phillips, M; Charman, SA; Matthews, D Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase US Patent US9238653 Publication Date 1/19/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Dihydroorotate dehydrogenase (quinone), mitochondrial |
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Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
Synonyms: | DHOdehase | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase homolog | Dihydroorotate oxidase | PYRD_PLAF7 |
Type: | Enzyme |
Mol. Mass.: | 65581.88 |
Organism: | Plasmodium falciparum (isolate 3D7) |
Description: | Q08210 |
Residue: | 569 |
Sequence: | MISKLKPQFMFLPKKHILSYCRKDVLNLFEQKFYYTSKRKESNNMKNESLLRLINYNRYY
NKIDSNNYYNGGKILSNDRQYIYSPLCEYKKKINDISSYVSVPFKINIRNLGTSNFVNNK
KDVLDNDYIYENIKKEKSKHKKIIFLLFVSLFGLYGFFESYNPEFFLYDIFLKFCLKYID
GEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKL
GFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEED
KLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKL
KNIILSVKEEIDNLEKNNIMNDESTYNEDNKIVEKKNNFNKNNSHMMKDAKDNFLWFNTT
KKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAK
LKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAV
QIKRELNHLLYQRGYYNLKEAIGRKHSKS
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BDBM50345406 |
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n/a |
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Name | BDBM50345406 |
Synonyms: | CHEMBL1784574 | N-(4-tert-Butyl-3-fluorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine | US9238653, Table 5, Compound 32 |
Type | Small organic molecule |
Emp. Form. | C16H18FN5 |
Mol. Mass. | 299.346 |
SMILES | Cc1cc(Nc2ccc(c(F)c2)C(C)(C)C)n2ncnc2n1 |
Structure |
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