| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Ligand | BDBM50018006 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibiton Assay |
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| pH | 8±n/a |
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| IC50 | 22±n/a nM |
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| Comments | extracted |
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| Citation |  Rathod, PK; Floyd, D; Burrows, J; Marwaha, A; Gujjar, R; Coteron-Lopez, J; Phillips, M; Charman, SA; Matthews, D Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase US Patent US9238653 Publication Date 1/19/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Synonyms: | DHOdehase | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase homolog | Dihydroorotate oxidase | PYRD_PLAF7 |
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| Type: | Enzyme |
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| Mol. Mass.: | 65581.88 |
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| Organism: | Plasmodium falciparum (isolate 3D7) |
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| Description: | Q08210 |
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| Residue: | 569 |
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| Sequence: | MISKLKPQFMFLPKKHILSYCRKDVLNLFEQKFYYTSKRKESNNMKNESLLRLINYNRYY
NKIDSNNYYNGGKILSNDRQYIYSPLCEYKKKINDISSYVSVPFKINIRNLGTSNFVNNK
KDVLDNDYIYENIKKEKSKHKKIIFLLFVSLFGLYGFFESYNPEFFLYDIFLKFCLKYID
GEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKL
GFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEED
KLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKL
KNIILSVKEEIDNLEKNNIMNDESTYNEDNKIVEKKNNFNKNNSHMMKDAKDNFLWFNTT
KKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAK
LKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAV
QIKRELNHLLYQRGYYNLKEAIGRKHSKS
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| BDBM50018006 |
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| n/a |
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| Name | BDBM50018006 |
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| Synonyms: | CHEMBL3289672 | US9238653, Table 5, Compound 49 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H7F8N5 |
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| Mol. Mass. | 397.2261 |
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| SMILES | Cc1cc(Nc2cc(F)c(c(F)c2)C(F)(F)F)n2nc(nc2n1)C(F)(F)F |
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| Structure | 
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