| Reaction Details |
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 | Report a problem with these data |
| Target | Oligo-1,6-glucosidase IMA1 |
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| Ligand | BDBM173544 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Baker's Yeast alpha-Glucosidase Inhibition Assay |
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| pH | 6.8±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | 3.741e+4± 9.5e+2 nM |
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| Comments | extracted |
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| Citation |  Zawawi, NK; Taha, M; Ahmat, N; Ismail, NH; Wadood, A; Rahim, F; Rehman, AU Synthesis, in vitro evaluation and molecular docking studies of biscoumarin thiourea as a new inhibitor of a-glucosidases. Bioorg Chem63:36-44 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Oligo-1,6-glucosidase IMA1 |
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| Name: | Oligo-1,6-glucosidase IMA1 |
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| Synonyms: | α-glucosidase | Alpha-glucosidase | Alpha-glucosidase (α-glucosidase) | IMA1 | MALX3_YEAST | Oligo-1,6-glucosidase |
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| Type: | Protein |
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| Mol. Mass.: | 68577.59 |
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| Organism: | Saccharomyces cerevisiae S288c (Baker's yeast) |
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| Description: | n/a |
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| Residue: | 589 |
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| Sequence: | MTISSAHPETEPKWWKEATFYQIYPASFKDSNDDGWGDMKGIASKLEYIKELGADAIWIS
PFYDSPQDDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMKFITDLVINHCSSEHEWF
KESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSYFGGSAWTFDEKTQEFYLRLFCS
TQPDLNWENEDCRKAIYESAVGYWLDHGVDGFRIDVGSLYSKVVGLPDAPVVDKNSTWQS
SDPYTLNGPRIHEFHQEMNQFIRNRVKDGREIMTVGEMQHASDETKRLYTSASRHELSEL
FNFSHTDVGTSPLFRYNLVPFELKDWKIALAELFRYINGTDCWSTIYLENHDQPRSITRF
GDDSPKNRVISGKLLSVLLSALTGTLYVYQGQELGQINFKNWPVEKYEDVEIRNNYNAIK
EEHGENSEEMKKFLEAIALISRDHARTPMQWSREEPNAGFSGPSAKPWFYLNDSFREGIN
VEDEIKDPNSVLNFWKEALKFRKAHKDITVYGYDFEFIDLDNKKLFSFTKKYNNKTLFAA
LNFSSDATDFKIPNDDSSFKLEFGNYPKKEVDASSRTLKPWEGRIYISE
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| BDBM173544 |
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| n/a |
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| Name | BDBM173544 |
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| Synonyms: | 1-(4-(bis(4-Hydroxy-2-oxo-2H-chromen-3-yl)methyl)phenyl)-3-(2-bromophenyl)-thiourea (1) |
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| Type | Small organic molecule |
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| Emp. Form. | C32H21BrN2O6S |
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| Mol. Mass. | 641.488 |
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| SMILES | Oc1c(C(c2ccc(NC(=S)Nc3ccccc3Br)cc2)c2c(O)c3ccccc3oc2=O)c(=O)oc2ccccc12 |
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| Structure | 
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