| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 2 [E165G] |
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| Ligand | BDBM175281 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In vitro Cyclooxygenase Inhibition Assay |
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| IC50 | 6.1e+3±n/a nM |
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| Citation |  Abdellatif, KR; Abdelgawad, MA; Elshemy, HA; Alsayed, SS Design, synthesis and biological screening of new 4-thiazolidinone derivatives with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile. Bioorg Chem64:1-12 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin G/H synthase 2 [E165G] |
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| Name: | Prostaglandin G/H synthase 2 [E165G] |
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| Synonyms: | COX2 | Cyclooxygenase-2 (COX-2) | PGH2_HUMAN | PTGS2 |
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| Type: | Protein |
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| Mol. Mass.: | 68932.84 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35354[E165G] |
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| Residue: | 604 |
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| Sequence: | MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFL
TRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADY
GYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVGKLLLRRKFIPDPQGS
NMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKY
QIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCD
VLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQ
NRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRV
AGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEAL
YGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEV
GFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKER
STEL
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| BDBM175281 |
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| n/a |
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| Name | BDBM175281 |
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| Synonyms: | 2-(4-(4-Isobutylphenyl)thiazol-2-ylimino)thiazolidin-4-one (4b) |
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| Type | Small organic molecule |
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| Emp. Form. | C16H17N3OS2 |
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| Mol. Mass. | 331.456 |
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| SMILES | CC(C)Cc1ccc(cc1)-c1csc(N=C2NC(=O)CS2)n1 |w:14.14| |
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| Structure | 
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