| Reaction Details |
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 | Report a problem with these data |
| Target | Oligo-1,6-glucosidase IMA1 |
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| Ligand | BDBM175315 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Baker's Yeast α-Glucosidase Inhibition Assay |
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| pH | 6.8±n/a |
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| IC50 | 8.44e+3± 7.6e+2 nM |
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| Comments | extracted |
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| Citation |  Zawawi, NK; Taha, M; Ahmat, N; Wadood, A; Ismail, NH; Rahim, F; Azam, SS; Abdullah, N Benzimidazole derivatives as new a-glucosidase inhibitors and in silico studies. Bioorg Chem64:29-36 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Oligo-1,6-glucosidase IMA1 |
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| Name: | Oligo-1,6-glucosidase IMA1 |
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| Synonyms: | α-glucosidase | Alpha-glucosidase | Alpha-glucosidase (α-glucosidase) | IMA1 | MALX3_YEAST | Oligo-1,6-glucosidase |
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| Type: | Protein |
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| Mol. Mass.: | 68577.59 |
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| Organism: | Saccharomyces cerevisiae S288c (Baker's yeast) |
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| Description: | n/a |
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| Residue: | 589 |
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| Sequence: | MTISSAHPETEPKWWKEATFYQIYPASFKDSNDDGWGDMKGIASKLEYIKELGADAIWIS
PFYDSPQDDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMKFITDLVINHCSSEHEWF
KESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSYFGGSAWTFDEKTQEFYLRLFCS
TQPDLNWENEDCRKAIYESAVGYWLDHGVDGFRIDVGSLYSKVVGLPDAPVVDKNSTWQS
SDPYTLNGPRIHEFHQEMNQFIRNRVKDGREIMTVGEMQHASDETKRLYTSASRHELSEL
FNFSHTDVGTSPLFRYNLVPFELKDWKIALAELFRYINGTDCWSTIYLENHDQPRSITRF
GDDSPKNRVISGKLLSVLLSALTGTLYVYQGQELGQINFKNWPVEKYEDVEIRNNYNAIK
EEHGENSEEMKKFLEAIALISRDHARTPMQWSREEPNAGFSGPSAKPWFYLNDSFREGIN
VEDEIKDPNSVLNFWKEALKFRKAHKDITVYGYDFEFIDLDNKKLFSFTKKYNNKTLFAA
LNFSSDATDFKIPNDDSSFKLEFGNYPKKEVDASSRTLKPWEGRIYISE
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| BDBM175315 |
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| n/a |
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| Name | BDBM175315 |
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| Synonyms: | (E)-4-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)-N'-(2-hydroxy-4-methoxybenzylidene) benzohydrazide (10) |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22N4O3 |
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| Mol. Mass. | 414.4565 |
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| SMILES | COc1ccc(\C=N\NC(=O)c2ccc(cc2)-c2nc3cc(C)c(C)cc3[nH]2)c(O)c1 |
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| Structure | 
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