| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 1 [L114A] |
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| Ligand | BDBM176676 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Quenching Assay |
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| Kd | 27±10 nM |
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| Citation |  Shapiro, PS; MacKerell, Jr., AD; Fletcher, S Non-ATP dependent inhibitors of extracellular signal-regulated kinase (ERK) US Patent US9115122 Publication Date 8/25/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Mitogen-activated protein kinase 1 [L114A] |
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| Name: | Mitogen-activated protein kinase 1 [L114A] |
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| Synonyms: | ERK2(L114A) | Erk2 | MK01_MOUSE | Mapk | Mapk1 | Prkm1 |
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| Type: | n/a |
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| Mol. Mass.: | 41236.57 |
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| Organism: | Mus musculus (mouse) |
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| Description: | P63085[L114A] |
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| Residue: | 358 |
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| Sequence: | MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQ
TYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLAKTQHLS
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTG
FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG
ILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRI
EVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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| BDBM176676 |
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| n/a |
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| Name | BDBM176676 |
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| Synonyms: | US9115122, 2.3.2 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H10O5S2 |
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| Mol. Mass. | 274.313 |
|---|
| SMILES | O=S(=O)(OC1CS(=O)(=O)C=C1)c1ccccc1 |c:9| |
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| Structure | 
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