| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 1 |
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| Ligand | BDBM176678 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Quenching Assay |
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| Kd | 1400±100 nM |
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| Citation |  Shapiro, PS; MacKerell, Jr., AD; Fletcher, S Non-ATP dependent inhibitors of extracellular signal-regulated kinase (ERK) US Patent US9115122 Publication Date 8/25/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 1 |
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| Name: | Mitogen-activated protein kinase 1 |
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| Synonyms: | ERT1 | Erk2 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK2) | MAP kinase 1 | MAP kinase 2 | MAP kinase ERK2 | MAPK 1 | MAPK 2 | MK01_MOUSE | Mapk | Mapk1 | Mitogen-activated protein kinase 2 | Prkm1 | p42 | p42-MAPK |
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| Type: | Protein |
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| Mol. Mass.: | 41278.65 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P63085 |
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| Residue: | 358 |
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| Sequence: | MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQ
TYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLS
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTG
FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG
ILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRI
EVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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| BDBM176678 |
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| n/a |
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| Name | BDBM176678 |
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| Synonyms: | US9115122, SF-2-054 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H15Cl2N5O2S2 |
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| Mol. Mass. | 456.369 |
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| SMILES | CCOc1ccc(\C=C2/SC(=S)N(CCNc3nc(Cl)nc(Cl)n3)C2=O)cc1 |
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| Structure | 
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