| Reaction Details |
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 | Report a problem with these data |
| Target | Lysosomal acid glucosylceramidase |
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| Ligand | BDBM175524 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Assay |
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| pH | 4.5±n/a |
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| Ki | 18630±1650 nM |
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| IC50 | 44960±3990 nM |
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| EC50 | 16400±2200 nM |
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| Comments | extracted |
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| Citation |  Wustman, BA Method for the treatment of neurological disorders by enhancing the activity of beta-glucocerebrosidase US Patent US9119845 Publication Date 9/1/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Lysosomal acid glucosylceramidase |
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| Name: | Lysosomal acid glucosylceramidase |
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| Synonyms: | Beta-glucocerebrosidase | GBA1_MOUSE | Gba | Gba1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 57628.24 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P17439 |
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| Residue: | 515 |
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| Sequence: | MAARLIGFFLFQAVSWAYGAQPCIPKSFGYSSVVCVCNASYCDSLDPVTLPALGTFSRYE
STRRGRRMELSVGAIQANRTGTGLLLTLQPEKKFQKVKGFGGAMTDATALNILALSPPTQ
KLLLRSYFSTNGIEYNIIRVPMASCDFSIRVYTYADTPNDFQLSNFSLPEEDTKLKIPLI
HQALKMSSRPISLFASPWTSPTWLKTNGRVNGKGSLKGQPGDIFHQTWANYFVKFLDAYA
KYGLRFWAVTAENEPTAGLFTGYPFQCLGFTPEHQRDFISRDLGPALANSSHDVKLLMLD
DQRLLLPRWAEVVLSDPEAAKYVHGIAVHWYMDFLAPAKATLGETHRLFPNTMLFASEAC
VGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVTGWTDWNLALNPEGGPNWVRNFVDSPI
IVDIPKDAFYKQPMFYHLGHFSKFIPEGSQRVALVASESTDLETVALLRPDGSAVVVVLN
RSSEDVPLTISDPDLGFLETVSPGYSIHTYLWRRQ
|
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|
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| BDBM175524 |
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| n/a |
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| Name | BDBM175524 |
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| Synonyms: | US9119845, 25 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H18N2O5 |
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| Mol. Mass. | 282.2924 |
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| SMILES | OC[C@@H]1[C@@H](O)[C@H](O)CCN1Cc1ccc(cc1)[N+]([O-])=O |r| |
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| Structure | 
|
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