| Reaction Details |
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 | Report a problem with these data |
| Target | Focal adhesion kinase 1 |
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| Ligand | BDBM176587 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Alpha Screen Assay |
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| pH | 7.4±n/a |
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| IC50 | 1.9±n/a nM |
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| Comments | extracted |
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| Citation |  Holmes, IP; Bergman, Y; Lunniss, GE; Nikac, M; Chol, N; Hemley, CF; Walker, SR; Foitzik, RC; Ganame, D; Lessene, R Selective FAK inhibitors US Patent US9120761 Publication Date 9/1/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Focal adhesion kinase 1 |
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| Name: | Focal adhesion kinase 1 |
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| Synonyms: | FAK1_MOUSE | Fadk | Fak | Fak1 | Focal adhesion kinase (FAK) | Kiaa4203 | Ptk2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 123537.99 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P34152 |
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| Residue: | 1052 |
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| Sequence: | MAAAYLDPNLNHTPSSSTKTHLGTGMERSPGAMERVLKVFHYFESSSEPTTWASIIRHGD
ATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEW
KYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMQEIADQVDQEIALKLGCLEIRRSY
WEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESI
LKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFNQVQ
TIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGATQSFII
RPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRE
RIELGRCIGEGQFGDVHQGVYLSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDH
PHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESK
RFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFT
SASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWA
YDPSRRPRFTELKAQLSTILEEEKVQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGY
PSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGIPAMAGSIYQGQASLLDQTELWNHRPQE
MSMWQPSVEDSAALDLRGMGQVLPPHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLS
RGSIDREDGSFQGPTGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLSNLSSISSPADSYNE
GVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLA
LRTLLATVDETIPALPASTHREIEMAQKLLNSDLGELISKMKLAQQYVMTSLQQEYKKQM
LTAAHALAVDAKNLLDVIDQARLKMLGQTRPH
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| BDBM176587 |
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| n/a |
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| Name | BDBM176587 |
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| Synonyms: | US9120761, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H29F3N6O2 |
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| Mol. Mass. | 514.5427 |
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| SMILES | COc1cc(ccc1Nc1ncc(c(CCc2ccccc2CC(N)=O)n1)C(F)(F)F)N1CCNCC1 |
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| Structure | 
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