| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 2 |
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| Ligand | BDBM178059 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | CA I and II Esterase Assay |
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| Ki | 587.64±29 nM |
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| IC50 | 389.76±0.0 nM |
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| Citation |  Artunç, T; Çetinkaya, Y; Göçer, H; Gülçin, Ä°; Menzek, A; Sahin, E; Supuran, CT Synthesis of 4-[2-(3,4-dimethoxybenzyl)cyclopentyl]-1,2-dimethoxybenzene Derivatives and Evaluations of Their Carbonic Anhydrase Isoenzymes Inhibitory Effects. Chem Biol Drug Des87:594-607 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 2 |
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| Name: | Carbonic anhydrase 2 |
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| Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
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| Type: | Enzyme |
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| Mol. Mass.: | 29250.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00918 |
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| Residue: | 260 |
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| Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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| BDBM178059 |
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| n/a |
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| Name | BDBM178059 |
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| Synonyms: | (3,4-dimethoxyphenyl)[2-(3,4-dimethoxyphenyl)cyclopentyl]methyl 4-nitrobenzoate (23) |
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| Type | Small organic molecule |
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| Emp. Form. | C29H31NO8 |
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| Mol. Mass. | 521.5583 |
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| SMILES | COc1ccc(cc1OC)C(OC(=O)c1ccc(cc1)[N+]([O-])=O)C1CCCC1c1ccc(OC)c(OC)c1 |
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| Structure | 
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