| Reaction Details |
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 | Report a problem with these data |
| Target | Methionine aminopeptidase 2 |
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| Ligand | BDBM178128 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Assays |
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| pH | 7.5±n/a |
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| IC50 | 6e+2± 1e+2 nM |
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| Comments | extracted |
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| Citation |  Morgen, M; Jöst, C; Malz, M; Janowski, R; Niessing, D; Klein, CD; Gunkel, N; Miller, AK Spiroepoxytriazoles Are Fumagillin-like Irreversible Inhibitors of MetAP2 with Potent Cellular Activity. ACS Chem Biol11:1001-11 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Methionine aminopeptidase 2 |
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| Name: | Methionine aminopeptidase 2 |
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| Synonyms: | Initiation factor 2-associated 67 kDa glycoprotein | MAP 2 | MAP2_HUMAN | METAP2 | MNPEP | MetAP 2 | Methionine aminopeptidase 2 (MetAP2) | Methionine aminopeptidases (HsMetAP2) | P67EIF2 | Peptidase M 2 | p67 |
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| Type: | Enzyme |
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| Mol. Mass.: | 52884.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P50579 |
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| Residue: | 478 |
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| Sequence: | MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKES
GASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPI
CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR
KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT
VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV
GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEV
YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL
DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
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| BDBM178128 |
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| n/a |
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| Name | BDBM178128 |
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| Synonyms: | isobutyl ((2'R*,7R*)-3-(4-methoxybenzyl)-3,5,6,7-tetrahydrospiro[benzo[d][1,2,3]triazole-4,2'-oxiran]-7-yl)carbamate (35) |
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| Type | Small organic molecule |
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| Emp. Form. | C20H26N4O4 |
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| Mol. Mass. | 386.4448 |
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| SMILES | COc1ccc(Cn2nnc3[C@@H](CC[C@]4(CO4)c23)NC(=O)OCC(C)C)cc1 |r| |
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| Structure | 
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