| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cyclin-dependent kinase 2 |
|---|
| Ligand | BDBM180843 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | CDK2/CycE Kinase Assay |
|---|
| pH | 8±n/a |
|---|
| Temperature | 295.15±n/a K |
|---|
| IC50 | 220±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Lücking, U; Kosemund, D; Scholz, A; Lienau, P; Siemeister, G; Bömer, U; Bohlmann, R Disubstituted 5-fluoro pyrimidine derivatives containing a sulfoximine group US Patent US9133171 Publication Date 9/15/2015 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cyclin-dependent kinase 2 |
|---|
| Name: | Cyclin-dependent kinase 2 |
|---|
| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 33938.17 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P24941 |
|---|
| Residue: | 298 |
|---|
| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
|
|
|
|---|
| BDBM180843 |
|---|
| n/a |
|---|
| Name | BDBM180843 |
|---|
| Synonyms: | US9133171, 48 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H19F2N5O2S |
|---|
| Mol. Mass. | 455.48 |
|---|
| SMILES | COc1cc(F)ccc1-c1nc(Nc2cccc(CS(=O)(=NC#N)C3CC3)c2)ncc1F |
|---|
| Structure | 
|
|---|
Search and Browse
