| Reaction Details |
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 | Report a problem with these data |
| Target | Urease |
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| Ligand | BDBM181086 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Urease Inhibition Assay |
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| pH | 6.8±n/a |
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| Temperature | 303.15±n/a K |
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| IC50 | 6.3e+3± 4.2e+2 nM |
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| Comments | extracted |
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| Citation |  Taha, M; Ismail, NH; Imran, S; Wadood, A; Rahim, F; Khan, KM; Riaz, M Hybrid benzothiazole analogs as antiurease agent: Synthesis and molecular docking studies. Bioorg Chem66:80-7 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Urease |
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| Name: | Urease |
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| Synonyms: | UREA_CANEN | Urea amidohydrolase |
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| Type: | Enzyme |
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| Mol. Mass.: | 90746.20 |
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| Organism: | Canavalia ensiformis (Jack bean) (Horse bean) |
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| Description: | P07374 |
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| Residue: | 840 |
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| Sequence: | MKLSPREVEKLGLHNAGYLAQKRLARGVRLNYTEAVALIASQIMEYARDGEKTVAQLMCL
GQHLLGRRQVLPAVPHLLNAVQVEATFPDGTKLVTVHDPISRENGELQEALFGSLLPVPS
LDKFAETKEDNRIPGEILCEDECLTLNIGRKAVILKVTSKGDRPIQVGSHYHFIEVNPYL
TFDRRKAYGMRLNIAAGTAVRFEPGDCKSVTLVSIEGNKVIRGGNAIADGPVNETNLEAA
MHAVRSKGFGHEEEKDASEGFTKEDPNCPFNTFIHRKEYANKYGPTTGDKIRLGDTNLLA
EIEKDYALYGDECVFGGGKVIRDGMGQSCGHPPAISLDTVITNAVIIDYTGIIKADIGIK
DGLIASIGKAGNPDIMNGVFSNMIIGANTEVIAGEGLIVTAGAIDCHVHYICPQLVYEAI
SSGITTLVGGGTGPAAGTRATTCTPSPTQMRLMLQSTDDLPLNFGFTGKGSSSKPDELHE
IIKAGAMGLKLHEDWGSTPAAIDNCLTIAEHHDIQINIHTDTLNEAGFVEHSIAAFKGRT
IHTYHSEGAGGGHAPDIIKVCGIKNVLPSSTNPTRPLTSNTIDEHLDMLMVCHHLDREIP
EDLAFAHSRIRKKTIAAEDVLNDIGAISIISSDSQAMGRVGEVISRTWQTADKMKAQTGP
LKCDSSDNDNFRIRRYIAKYTINPAIANGFSQYVGSVEVGKLADLVMWKPSFFGTKPEMV
IKGGMVAWADIGDPNASIPTPEPVKMRPMYGTLGKAGGALSIAFVSKAALDQRVNVLYGL
NKRVEAVSNVRKLTKLDMKLNDALPEITVDPESYTVKADGKLLCVSEATTVPLSRNYFLF
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| BDBM181086 |
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| n/a |
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| Name | BDBM181086 |
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| Synonyms: | 2-(4-(benzo[d]thiazol-2-yl)benzoyl)-N-(3-fluorophenyl)hydrazinecarbothioamide (12) |
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| Type | Small organic molecule |
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| Emp. Form. | C21H15FN4OS2 |
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| Mol. Mass. | 422.498 |
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| SMILES | Fc1cccc(NC(=S)NNC(=O)c2ccc(cc2)-c2nc3ccccc3s2)c1 |
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| Structure | 
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