| Reaction Details |
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 | Report a problem with these data |
| Target | Urease subunit alpha |
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| Ligand | BDBM181107 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Urease Inhibition Assay |
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| Temperature | 303.15±n/a K |
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| IC50 | 5.62e+4± 1.2e+3 nM |
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| Comments | extracted |
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| Citation |  Rashid, U; Rahim, F; Taha, M; Arshad, M; Ullah, H; Mahmood, T; Ali, M Synthesis of 2-acylated and sulfonated 4-hydroxycoumarins: In vitro urease inhibition and molecular docking studies. Bioorg Chem66:111-6 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Urease subunit alpha |
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| Name: | Urease subunit alpha |
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| Synonyms: | URE1_SPOPA | Urea Amidohydrolase Subunit alpha | Urease | ureC |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 61384.55 |
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| Organism: | Bacillus pasteurii |
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| Description: | n/a |
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| Residue: | 569 |
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| Sequence: | MKINRQQYAESYGPTVGDRVRLADTDLGEVEKDYYYLGDEVNFGGGKVLREGMGENGTYT
RTENVLDLLLTNALILDYTGIYKADIGVKDGYIVGIGKGGNPDIMDGVTPNMIVGTATEV
IAAEGKIVTAGGIDTHVHFINPDQVDVALANGITTLFGGGTGPAEGSKATTVTPGPWNIE
KMLKSTEGLPINVGILGKGHGSSIAPIMEQIDAGAAGLKIHEDWGATPASIDRSLTVADE
ADVQVAIHSDTLNEAGFLEDTVRAINGRVIHSFHVEGAGGGHAPDIMAMAGHPNVLPSST
NPTRPFTVNTIDEHLDMLMVCHHLKQNIPEDVAFADSRIRPETIAAEDILHDLGIISMMS
TDALAMGRAGEMVLRTWQTADKMKKQRGPLAEEKNGSDNFRLKRYVSKYTINPAIAQGMA
HEVGSIEEGKFADLVLWEPKFFGVKADRVIKGGIIAYAQIGDPSASIPTPQPVMGRRMYG
TVGDLIHDTNITFMSKSSIQQGVPAKLGLKRRIGTVKNCRNIGKKDMKWNDVTTDIDINP
ETYEVKVDGEVLTCEPVKELPMAQRYFLF
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| BDBM181107 |
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| n/a |
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| Name | BDBM181107 |
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| Synonyms: | 3-(3-Nitrobenzosulfonyl)-(4-hydroxycoumarin) (14) |
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| Type | Small organic molecule |
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| Emp. Form. | C16H11NO7S |
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| Mol. Mass. | 361.326 |
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| SMILES | Oc1c(c(=O)oc2ccccc12)S(=O)(=O)Cc1cccc(c1)[N+]([O-])=O |
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| Structure | 
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