| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 3A4 |
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| Ligand | BDBM50015234 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In vitro CYP3A4 Inhibition Assay |
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| IC50 | >10000±n/a nM |
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| Citation |  Bareja, SP; Jones, SD; Oblong, JE; Mills, KJ; Bierman, JC Cosmetic compositions containing substituted azole and methods for alleviating the signs of photoaged skin US Patent US9144538 Publication Date 9/29/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 3A4 |
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| Name: | Cytochrome P450 3A4 |
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| Synonyms: | Albendazole monooxygenase | Albendazole sulfoxidase | CP3A4_HUMAN | CYP3A3 | CYP3A4 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 3A4 (CYP3A4) | Cytochrome P450 HLp | Nifedipine oxidase | Quinine 3-monooxygenase | Taurochenodeoxycholate 6-alpha-hydroxylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 57349.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 503 |
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| Sequence: | MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF
DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI
AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS
MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV
FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI
IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV
NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS
KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG
GLLQPEKPVVLKVESRDGTVSGA
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| BDBM50015234 |
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| n/a |
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| Name | BDBM50015234 |
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| Synonyms: | 4,4''[1,6-HEXANEDIYLBIS(OXY)]BISBENZENECARBOXIMIDAMIDE | 4-[6-(4-Carbamimidoyl-phenoxy)-hexyloxy]-benzamidine | 4-{6-[4-amino(imino)methylphenoxy]hexyloxy}phenyl-iminomethanamine | 4-{6-[4-ammino(imino)methylphenoxy]hexyloxy}phenyl-iminomethanammine | CHEMBL25105 | Hexamidine | US9138393, Hexamidine diisethionate | US9144538, Hexamidine diisethionate |
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| Type | Small organic molecule |
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| Emp. Form. | C20H26N4O2 |
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| Mol. Mass. | 354.446 |
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| SMILES | NC(=N)c1ccc(OCCCCCCOc2ccc(cc2)C(N)=N)cc1 |
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| Structure | 
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